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Monoclonal B Cells in Peripheral Blood in Non‐Hodgkin's Lymphoma. Correlation with Clinical Features and DNA Content
Author(s) -
Lindh Jack,
Lenner Per,
Roos Göran
Publication year - 1984
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1984.tb00670.x
Subject(s) - lymphoma , peripheral blood , malignancy , medicine , monoclonal , flow cytometry , pathology , lymphocyte , monoclonal antibody , peripheral blood lymphocyte , population , peripheral , stage (stratigraphy) , non hodgkin's lymphoma , immunology , biology , antibody , paleontology , environmental health
Peripheral blood from 69 patients with non‐Hodgkin's lymphoma was examined with respect to B and T cell markers. Evidence for monoclonal B cell was found in 29 cases, 8 of ‘high grade’ and 21 of ‘low grade’ malignancy according to the Kiel classification. 17 out of the 29 patients had a normal lymphocyte count. Using conventional staging methods 4 cases of the 29 were in stages II and III, all others in stage IV. The proportion of S‐phase cells in peripheral blood, determined by flow cytometry, was found to be elevated in cases with a monoclonal cell population. It is concluded that surface marker analysis of blood cells may be valuable as a diagnostic tool, as an indicator of prognosis and perhaps for the staging procedure of malignant lymphomas.