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Peripheral Blood Lymphocyte Subpopulations in Polycythaemia and Thrombocythaemia
Author(s) -
Eridani Sandro,
Fiorini Gian Francesco,
Batten Elaine
Publication year - 1983
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1983.tb02536.x
Subject(s) - polycythaemia , immunology , platelet , peripheral blood , monoclonal antibody , lymphocyte , medicine , antibody , peripheral , t lymphocyte , monocyte , antiserum , monoclonal , immune system
Lymphocyte subpopulations from peripheral blood of normal subjects and patients with primary proliferative polycythaemia (PPP), idiopathic erythrocytosis (IE) and essential thrombocythaemia (ET) were separated using antihuman immunoglobulin antiserum for B lymphocytes and the following monoclonal antibodies: OKT3, directed against the general T‐lymphocyte subpopulation, OKT4 amd OKT8, detecting respectively T‐helper and T‐suppressor lymphocyte subpopulations, OKM1 reacting mainly with monocytes. A decrease in the number of OKT3 + cells was observed both in PPP and IE, with a particular fall of the OKT8 + (suppressor) cells, so that the T4/T8 ratio was significantly increased (P < 0.03 in PPP and P < 0.0005 in IE). The ratio remained normal in samples from ET. OKM1 + cells were significantly increased in PPP (P < 0.04), but not in IE, while in ET there was a rise in a few cases only. The present data point out some definite changes in the circulating lymphomonocytic cell subsets, which may be of interest in the study of this group of myeloproliferative disorders.