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Comparative Studies of the in Vivo Kinetics of Simultaneously Injected 111 In‐ and 51 Cr‐Labelled Human Platelets
Author(s) -
Schmidt Kai Gjerløff,
Rasmussen Jens Wæver,
Rasmussen Anker Dahl,
Arendrup Henrik
Publication year - 1983
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1983.tb02535.x
Subject(s) - platelet , in vivo , chemistry , kinetics , labelling , medicine , biochemistry , biology , physics , microbiology and biotechnology , quantum mechanics
The kinetics of simultaneously injected 111 In‐ and 51 Cr‐labelled platelets have been assessed in 40 subjects, 13 of them thrombocytopenic. 4 platelet survival models were applied. The mean life‐time (MLT) of 51 Cr‐platelets from non‐thrombocytopenic individuals was found to be slightly, but significantly, longer than that of 111 In‐platelets by applying linear and exponential models for data fitting. The in vivo recovery (IVR) of 111 In‐platelets was significantly higher than that of 51 Cr‐platelets in this patient group when using all 4 models. In the group of thrombocytopenic patients no statistically significant differences in MLT or IVR were found between 111 In‐ and 51 Cr‐platelets. However, for each of the 11 51 Cr‐labelled platelet suspensions with the shortest MLT, a longer MLT was observed in the corresponding 111 In‐platelets, a finding probably related to antibody‐induced elution of 51 Cr‐activity. The same mechanism might be responsible for an increasing 111 In‐/ 51 Cr‐recovery ratio in the early post‐injection period. The efficiency of platelet isolation from blood prior to labelling seemed to influence the IVR, inasmuch as the difference in IVR between 111 In‐ and 51 Cr‐platelets was eliminated in the group where the yield of 111 In‐platelets surpassed that of the 51 Cr‐platelets by more than 15 %.