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Low antithrombin in severe disease: Consumption or decreased synthesis?
Author(s) -
ANKER ERIK,
ABILDGAARD ULRICH,
ANDERSEN RAGNAR,
FAGERHOL MAGNE,
BJUNE GUNNAR
Publication year - 1983
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1983.tb02157.x
Subject(s) - antithrombin , albumin , liver disease , medicine , gastroenterology , disseminated intravascular coagulation , coagulation , transthyretin , disease , fibrinogen , c reactive protein , inflammation , heparin
Haemostasis parameters alone are often insufficient in distinguishing between disseminated intravascular coagulation (DIC) and liver disease. We have determined the concentration of five additional plasma proteins in 6 patients with DIC and 10 patients with liver disease. All patients had antithrombin III (AT) and normotest (NT) levels at 60 per cent or lower. Prealbumin and albumin were clearly subnormal in all patients with similar mean values in both two groups. It is suggested that this might reflect insufficient protein synthesis even in the patients with DIC. The mean fibronectin concentration was somewhat lower in DIC than in the group with liver disease. C reactive protein (CRP) and the leucocyte derived protein LI were much higher in the DIC patients, probably reflecting the underlying infection.