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Lymphocyte Subpopulations in Benign Monoclonal Gammopathy
Author(s) -
Silvian I.,
Carter A.,
Tatarsky I.,
Spira G.
Publication year - 1983
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1983.tb02140.x
Subject(s) - multiple myeloma , monoclonal antibody , monoclonal , medicine , lymphocyte , monoclonal gammopathy , monoclonal gammopathy of undetermined significance , immunology , immunofluorescence , lymphocyte subsets , t lymphocyte , pathology , antibody , antigen , cd8
Peripheral blood samples from normal individuals and from patients with benign monoclonal gammopathy or multiple myeloma were separated and assayed by immunofluorescence and rosette formation for T, B, T G and T M subpopulations. When compared with normal individuals and multiple myeloma patients, the benign monoclonal gammopathy patients could be divided into 2 groups. The 1st group demonstrated a T/B ratio similar to normal individuals, whereas in the 2nd group the ratio resembled that of the myeloma patients, with a decrease in the fraction of T lymphocytes, accompanied by an increased number of B lymphocytes. An analysis of the monoclonal Ig fraction levels indicated that the 2 groups differ in this respect as well. In the 1st group, the level of the monoclonal immunoglobulin was stable, with small fluctuations. The 2nd group demonstrated a general increasing M‐component, especially in the 4–6 months preceding the study. The 2 benign monoclonal gammopathy groups exhibited a trend to a lower T M /T G ratio compared to normals; this change is more prominent in the 2nd group. Analysis of the T lymphocyte subpopulations indicated an overall decrease in the fraction of T M multiple myeloma. The above‐mentioned parameters might thus aid in discriminating among BMG patients with regard to their tendency towards a malignant transformation.