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Why Concentration of Serum Ferritin does not in All Circumstances Reflect Storage Iron but is Still of Value in its Estimation
Author(s) -
Rajantie J.,
Siimes M. A.
Publication year - 1983
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1983.tb02131.x
Subject(s) - ferritin , serum ferritin , diabetes mellitus , endocrinology , hemochromatosis , medicine , chemistry
We describe a 10‐year‐old girl with familial haemochromatosis which is associated with a normal concentration of S‐ferritin, myocardial disease and diabetes mellitus. We speculate that iron is accumulated primarily in the heart and pancreas as such isoferritins are not detected by the routine assay of serum ferritin based on antispleen or placenta ferritin. Further, this condition is compared with lysinuric protein intolerance, an inborn error of diamino‐acid transport where an opposite discrepancy between S‐ferritin and storage iron is seen.