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Eosinophilic Granulocytes as a Possible Source of Vitamin B 12 ‐Binding Protein
Author(s) -
Mansouri Ali,
Perry Carol A.,
Boyd Charles M.,
Hsu ShuDean
Publication year - 1983
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1983.tb01553.x
Subject(s) - eosinophilic , vitamin b , vitamin b12 , immunology , myeloid , myeloproliferative disorders , iron binding proteins , granulocyte , chemistry , eosinophil , biology , microbiology and biotechnology , biochemistry , vitamin , genetics , gene , asthma
Leucocyte B 12 and B 12 ‐binding capacity were measured by Simultrac radioassay in eosinophilic granulocytes, neutrophilic granulocytes and leucocytes obtained from patients with chronic granulocytic and lymphocytic leukaemia. It is shown that (a) eosinophils are a possible source of B 12 ‐binding protein similar to neutrophils and (b) granulocytes in myeloproliferative disorders and normal neutrophils have similar B 12 and B 12 ‐binding capacity indicating that increased B 12 and B 12 ‐binding capacity in myeloproliferative disorders arise from an increase in myeloid cell turnover.