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High‐Dose Intravenous Immunoglobulin for Post‐Transfusion Purpura
Author(s) -
Glud Torben K.,
Rosthøj Steen,
Jensen Mogens Krogh,
Laursen Benedicte,
Grunnet Niels,
Jersild Casper
Publication year - 1983
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1983.tb01551.x
Subject(s) - medicine , platelet , purpura (gastropod) , antibody , surgery , body weight , platelet transfusion , blood transfusion , anesthesia , gastroenterology , immunology , ecology , biology
Successful treatment of a case of post‐transfusion purpura with high‐dose i.v. human immunoglobulin is reported. A 62‐year‐old multiparous woman developed severe thrombocytopenia in the wake of transfusions given during and after vascular surgery. A platelet alloantibody with anti‐Zw a ‐specificity was demonstrable by an indirect immunofluorescence technique. A single infusion of Sandoglobulin® 1 g/kg body weight caused an immediate platelet response with cessation of haemorrhagic manifestations within 12 h, and the platelet count became normal within 3 d. Thrombocytopenia recurred 8 d after the infusion, but one further dose of Sandoglobulin 0.5 g/kg body weight caused definitive reversal of the thrombocytopenia.