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Effect of Prophylactic High‐Dose Treatment with Ampicillin and Cloxacillin on Bleeding Time and Bleeding in Patients Undergoing Elective Vascular Surgery
Author(s) -
Wisløff F.,
Larsen J. Pillgram,
Dahle A.,
Lie M.,
Godal H. C.
Publication year - 1983
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1983.tb01515.x
Subject(s) - cloxacillin , medicine , antibiotics , surgery , bleeding time , ampicillin , anesthesia , heparin , major bleeding , platelet aggregation , platelet , microbiology and biotechnology , biology , myocardial infarction
50 patients undergoing elective vascular surgery were randomized to prophylactic antibiotic treatment with ampicillin 2 g times; 4 + cloxacillin 1 g times; 4 for 4 d following the operation, or to a control group without antibiotics. All patients received heparin subcutaneously 5000 IU × 2, for 7 d. On days 1 and 4 after the operation, the median bleeding time was 1 1/2‐2 min longer in the antibiotics group. 5 patients on antibiotics had a bleeding time prolongation beyond the normal range, but only 2 of these, who had additional haemostatic defects, had abnormal bleeding.