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Protective Effect of Implanted Autologous Splenic Tissue in Splenectomized Rats Exposed to i.v. Streptococcus Pneumoniae
Author(s) -
Nielsen Johan Lanng,
Andersen Hans M. Kerzel,
Hansen Knud Bendix,
Saksø Peter,
Kristensen Erik Skoubo,
Sørensen Finn Hanberg
Publication year - 1983
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1983.tb01508.x
Subject(s) - splenectomy , streptococcus pneumoniae , spleen , medicine , inoculation , animal model , surgery , gastroenterology , pathology , biology , microbiology and biotechnology , antibiotics
The protective effect of splenic implantation or hemisplenectomy on the survival rate was studied in 34 Wistar rats inoculated intravenously with 8.5 × 10 6 CFU Streptococcus pneumoniae type 25. 4 months prior to the bacterial challenge, different surgical procedures were performed, dividing the animals into 5 equally large groups: (1) sham operation, (2) hemisplenectomy, (3) splenectomy with a 100% reimplantation, (4) splenectomy with a 50% reimplantation, and (5) splenectomy without reimplantation. The observation period after the bacterial inoculation was 13 d. Differences in mean survival rates were found: (1) 13 d, (2) 10.6 d, (3) 7.1 d, (4) 5.6 d, and (5) 3.1 d. The increasing survival rates correlated with increasing weights of the residual splenic tissue. This animal study indicates that residual splenic tissue may account for a lesser tendency to infection.