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Kinetics of Indium‐111‐Labelled T Lymphocytes in a Patient with Adult T‐Cell Leukaemia
Author(s) -
Yamauchi Kunihiko,
Nagao Tadami,
Sugihara Masami,
Suzuki Yutaka
Publication year - 1983
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1983.tb01505.x
Subject(s) - lymph , spleen , lymph node , axillary lymph nodes , inguinal lymph nodes , infiltration (hvac) , pathology , t lymphocyte , lymphocyte , phagocytosis , medicine , immunology , immune system , metastasis , physics , cancer , thermodynamics
Clinical studies using indium‐111 oxine labelling of leukaemic T lymphocytes from a patient with adult T‐cell leukaemia are presented. Leukaemic T lymphocytes did not take less than 48 h to traverse the spleen. This result was different from that of normal subjects, in which T lymphocytes continue to fall up to 44 h after the initial rise. Liver activity was seen to accumulate progressively up to 68 h. This could be explained by the infiltration of the liver by T lymphocytes or phagocytosis of damaged T lymphocytes due to Kupffer cells. Leukaemic T lymphocytes entered the enlarged, inguinal lymph nodes at 3 h and left after 68 h, but few T lymphocytes crossed the axillary lymph nodes, which were enlarged as much as the inguinal lymph nodes. This observation suggests that the degree of migration of leukaemic T lymphocytes to each lymph node differs.