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The Nature of Hairy Cells ‐ A Study with a Panel of Monoclonal Antibodies
Author(s) -
Worman C. P.,
Brooks D. A.,
Hogg N.,
Zola H.,
Beverley P. C. L.,
Cawley J. C.
Publication year - 1983
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1983.tb01479.x
Subject(s) - monoclonal antibody , hairy cell , antibody , hairy cell leukemia , stain , microbiology and biotechnology , monocyte , cell , monoclonal , immunology , macrophage , peripheral blood , medicine , chemistry , biology , pathology , staining , biochemistry , leukemia , in vitro
In all 11 patients with hairy‐cell leukaemia (HCL) tested, a high percentage of peripheral blood and splenic (3 cases) hairy cells (HCs) reacted with 2 B‐cell‐specific monoclonal antibodies (FMC1 and FMC7), but failed to stain with 5 monocyte/macrophage‐specific (FMC17, UCHM1, SM1, SMΦ and OKM1) and with 4 T‐cell‐specific antibodies (UCHT1, Leu1, 2a and 3a). The data provide further evidence in support of the B‐cell nature of the HCs of HCL.