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Malignant Histiocytosis
Author(s) -
ØSterJørgensen Erik,
Rønne Mogens,
Jensen Niels Kristoffer,
Grunnet Niels
Publication year - 1983
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1983.tb01465.x
Subject(s) - malignant histiocytosis , medicine , pathology , bone marrow , histiocyte , bleomycin , complication , histiocytosis , infiltration (hvac) , biopsy , disease , surgery , chemotherapy , physics , thermodynamics
A 38‐year‐old female suffered for several months from persistent fever without signs of infectious or immunologic disease. 57 Co‐bleomycin scintigraphy revealed abnormal concentration in the liver. Following a diagnostic laparotomy, the patient died from abdominal haemorrhage. Malignant cell infiltration was demonstrated in a biopsy from the liver. Histiocytic cells were demonstrated in a bone marrow smear obtained shortly before death. Investigation of cultured lymphocytes obtained from the patient the day before she died showed deficiency of T‐lymphocytes. Investigations of chromosomes delineated several clones with polyploidi. The diagnosis of malignant histiocytosis was based on erythrophagocytosis, and immunologic and chromosomal aberrations. If malignant histiocytosis is the primary disease, a terminal stage of different diseases or a sign of complication secondary to immuno incompetence (e.g. virus infection) is an open question.