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Haematopoietic Progenitors in Essential Thrombocythaemia
Author(s) -
Partanen Seija,
Ruutu Tapani,
Vuopio Pekka
Publication year - 1983
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1983.tb01457.x
Subject(s) - progenitor cell , haematopoiesis , bone marrow , peripheral blood , colony forming unit , immunology , biology , platelet , microbiology and biotechnology , stem cell , genetics , bacteria
Colony formation by haematopoietic progenitors from the bone marrow and blood of 4 patients with essential thrombocythaemia was studied in vitro using the methyl cellulose assay. 3 patients had clearly elevated numbers of BFU‐E in bone marrow. 1 patient also had markedly increased numbers of CFU‐E and CFU‐GM, whereas the other patients had only marginally increased or normal numbers of these progenitors in the marrow. 3 patients showed markedly increased numbers of all progenitors in peripheral blood. All 4 patients showed spontaneous erythroid colony formation by progenitors from the bone marrow and 2 had spontaneous colony formation by progenitors from the blood. We conclude that essential thrombocythaemia shows abnormal colony formation in line with other myeloproliferative syndromes.