Premium
Influence of the Spleen on the Distribution of Blood Neutrophils
Author(s) -
Rohrer C.,
Arni U.,
Deubelbeiss K. A.
Publication year - 1983
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1983.tb01451.x
Subject(s) - spleen , marginal zone , distribution (mathematics) , immunology , medicine , biology , antibody , mathematical analysis , mathematics , b cell
The influence of the spleen on the distribution of blood neutrophils was studied in rats with varying spleen sizes following transfusion of isologous 3 H‐dT‐labelled neutrophils. The weight of the spleen correlated with the splenic neutrophil pool (r = 0.87, P < 0.01). Alterations in spleen size did not significantly change the total blood neutrophil pool, but with increasing splenomegaly circulating and marginal neutrophils were shifted into the splenic pool. With massive splenomegaly, up to 50% of the total blood neutrophils were trapped in the spleen. These findings suggest splenic pooling of neutrophils and a shift of circulating and marginal neutrophils into the spleen proportionate to the splenic tissue present.