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Density Distribution and Size of Megakaryocytes in Inflammatory Reactions of the Bone Marrow (Myelitis) and Chronic Myeloproliferative Diseases
Author(s) -
Thiele J.,
Holgado S.,
Choritz H.,
Georgii A.
Publication year - 1983
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1983.tb00661.x
Subject(s) - polycythaemia , polycythemia vera , bone marrow , myelofibrosis , pathology , megakaryocyte , medicine , myelitis , polycythemia rubra vera , immunology , biology , haematopoiesis , spinal cord , stem cell , psychiatry , genetics
Morphometric evaluation was performed on semi‐thin sections of core biopsies of the bone marrow and included 20 cases of each group of diseases besides control specimens. (i) Hyperergic myelitis of rheumatic origin. (ii) Chronic granulocytic leukaemia (CGL). (iii) Polycythaemia vera (P. vera). (iv) Chronic megakaryocytic‐granulocytic myelosis (CMGM). (v) Myelofibrosis or osteomyelosclerosis (MF/OMS). The following classification of megakaryopoiesis was applied: normal megakaryocytes; giant forms; microforms; intussusceptions; cytoplasmic fragments; naked nuclei. The density distribution shows an increase of megakaryocyte number in those 5 different marrow disorders, ranging from about 13/mm 2 in the normal sample up to 65 cells/mm 2 in MF/OMS. Microforms are most frequently encountered in CGL, whereas giant megakaryocytes, intussusceptions and many cytoplasmic fragments characterize P. vera, CMGM and MF/OMS. Our measurements suggests 3 distinct categories of bone marrow lesions with corresponding alterations of the megakaryopoiesis: (i) myelitis and CGL; (ii) P. vera; (iii) CMGM and MF/OMS.