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Displacement of T Lymphocytes with the ‘Helper/Inducer’ Phenotype from Peripheral Blood to Lymphoid Organs in Untreated Patients with Hodgkin's Disease
Author(s) -
Romagnani S.,
Prete G. F. Del,
Maggi E.,
Bosi A.,
Bernardi F.,
Ponticelli P.,
Lollo S. Di,
Ricci M.
Publication year - 1983
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1983.tb00658.x
Subject(s) - lymphocytopenia , cytotoxic t cell , monoclonal antibody , phenotype , peripheral blood mononuclear cell , immunology , inducer , antigen , immune system , lymphatic system , lymph , antibody , t lymphocyte , pathology , biology , lymphocyte , medicine , in vitro , biochemistry , gene
A panel of previously characterized monoclonal antibodies: B67.6, OKT3, OKT4, B53.4, Leu3a, OKT8, Leu2a, OKM1, M12 and B52.1 were used as a probe to assess mononuclear cells in peripheral blood (PB), lymph nodes (LN) and spleens of untreated patients with Hodgkin's disease (HD). The mean % and absolute number of T lymphocytes were significantly decreased in PB of HD patients when compared with control values. Reduction of circulating T lymphocytes reflected the selective loss of cells showing the ‘helper/inducer’ (‘H/I’) phenotype. In fact, a lower number of these cells was demonstrated in HD patients with advanced disease and, even though to a lesser extent, in those with localized disease. In contrast, decreased values of T cells with the ‘cytotoxic/syppressor’ (‘C/S’) phenotype were only found in patients with advanced disease, showing pan‐lymphocytopenia. Unlike PB, LN and spleens involved by HD usually showed increased %s of T lymphocytes, especially of those possessing the ‘H/I’ phenotype. The displacement of T lymphocytes with ‘H/I’ phenotype from PB to lymphoid organs further supports the possibility of a chronic immune response against abnormal cells or unknown antigens in the affected organs of patients with HD.