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Lithium Therapy for Cyclic Neutropenia in Children
Author(s) -
Ishii Eiichi,
Hara Toshiro,
Miyazaki Sumio,
Fujiwara Takashi,
Goya Nagahide
Publication year - 1983
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1983.tb00640.x
Subject(s) - neutropenia , medicine , discontinuation , lithium carbonate , stomatitis , cyclic neutropenia , pediatrics , surgery , chemotherapy , ion , physics , quantum mechanics , ionic bonding
2 children with cyclic neutropenia were treated with lithium carbonate. In one patient, fever and stomatitis were ameliorated, but the duration of neutropenia was increased and parotitis occurred. In another patient, aphthous stomatitis disappeared but fever persisted. The duration of neutropenia was prolonged and submaxillaritis and sinusitis occurred. Thus, lithium administration may lead to complications when the duration of neutropenia is prolonged. We recommend discontinuation of the drug, even in the presence of amelioration of symptoms.