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Blood and Lymph Node T‐Lymphocyte Subsets in Non‐Hodgkin Lymphomas
Author(s) -
LINDEMALM C.,
MELLSTEDT H.,
BIBERFELD P.,
BJÖRKHOLM M.,
CHRISTENSSON B.,
HOLM G.,
JOHANSSON B.,
SUNDBLAD R.
Publication year - 1983
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1983.tb00636.x
Subject(s) - monoclonal antibody , lymph node , lymphoma , cytotoxic t cell , lymphocyte , lymph , immunology , t lymphocyte , monoclonal , rosette (schizont appearance) , medicine , antibody , biology , pathology , in vitro , antigen , biochemistry
Blood and lymph node T‐lymphocyte subpopulations have been studied in untreated non‐Hodgkin lymphoma (NHL) patients and healthy controls. T‐lymphocytes were determined by the E‐rosette technique and by OKT3/LEU4 monoclonal antibodies; OKT4/LEU3 and OKT8/LEU2 monoclonal antibodies were used to identify T‐cell subsets with helper/inducer and suppressor/cytotoxic activity, respectively. OKT4 + T‐cells were low in patients, while OKT8 + T‐cell numbers were normal. The OKT4 + /OKT8 + blood lymphocyte ratio was below the normal range in about 50% of the patients. The ratio was higher in lymph nodes than in blood of patients and controls. The results may suggest that untreated NHL patients have a reduced pool of T‐cells with phenotypic markers of OKT4/LEU3. Monoclonal blood B‐lymphocytes were found in 45% of the cases. The presence of such cells in blood was frequently associated with a low OKT4 + /OKT8 + ratio.