Premium
IgM Lambda Globular Cytoplasmic Inclusions in Chronic Lymphocytic Leukaemia Resembling Immunocytoma
Author(s) -
Berrebi A.,
Talmor M.,
Vorst E.,
Resnitzky P.,
Shtalrid M.
Publication year - 1983
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1983.tb00633.x
Subject(s) - pathology , lymph node , immunofluorescence , cytoplasmic inclusion , endoplasmic reticulum , chronic lymphocytic leukemia , medicine , cytoplasm , biology , antibody , immunology , leukemia , biochemistry
In a 64‐year‐old female with chronic lymphocytic leukaemia, nearly 50 % of the lymphocytes presented one or several globular intracytoplasmic inclusions resembling Russell bodies which were characterized by immunofluorescence as IgM lambda. On electron microscopy, the inclusions looked like cisternae of the rough endoplasmic reticulum. Surface membrane Ig was not detected and the serum IgM was low. The histology of a lymph node showed a lymphocytic proliferation with evidence of Ig synthesis, compatible with immunocytoma. The aggressive course of the disease necessitated polychemotherapy. This case represents an unusual ill‐defined lymphoproliferative disorder, lying between the B‐CLL and a non‐secretory macroglobulinaemia.