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Fetal Liver Transplantation in 2 Patients with Acute Leukaemia after Total Body Irradiation
Author(s) -
Lucarelli Guido,
Izzi Teodosio,
Porcellini Adolfo,
Delfini Costantino,
Galimberti Mariella,
Moretti Luciano,
Polchi Paola,
Agostinelli Fabrizio,
Andreani Marco,
Manna Marisa,
Dallapiccola Bruno
Publication year - 1982
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1982.tb02122.x
Subject(s) - total body irradiation , fetus , cyclophosphamide , medicine , bone marrow , haematopoiesis , transplantation , immunology , pathology , gastroenterology , biology , chemotherapy , pregnancy , stem cell , genetics
2 patients with acute leukaemia in relapse were transplanted with fetal liver cells following a conditioning regimen of cyclophosphamide (120 mg/kg) and total body irradiation (1000 r). Each patient achieved a remission with haematopoietic recovery that was rapid in one case and delayed in the other. In one case there was evidence of chimerism as demonstrated by the presence of the XYY karyotype of the donor fetus in 20% of marrow metaphases, by the presence of double Y bodies in the peripheral blood, by the appearance of new HLA‐antigens, and by red cell isoenzyme phenotypes of donor origin. In the second case there was prompt haemotopoietic recovery and the appearance of red cell isoenzyme phenotypes of donor origin. Survival was 153 and 30 d, respectively, and both patients died of interstitial pneumonia without evidence of graft versus host disease.