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Vinblastine‐Induced Erythrocytotoxicity
Author(s) -
Neville Alan J.,
Rand Carol A.,
Barr Ronald D.
Publication year - 1982
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1982.tb02117.x
Subject(s) - vinblastine , in vitro , red cell , red blood cell , drug , pharmacology , clinical significance , chemistry , biology , immunology , medicine , pathology , biochemistry , chemotherapy
At a therapeutic concentration (10 −6 mol/l), vinblastine causes no significant changes of erythrocyte morphology in whole blood in vitro, but, with 30% red cell suspensions in buffer, the drug is stomatocytogenic. Several pathogenetic mechanisms are considered and the clinical relevance of this finding is assessed.