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Platelet Function and Fibrinolytic Activity Following Distance Running
Author(s) -
Knudsen J. Bjerre,
Brodthagen U.,
Gormsen J.,
Jordal R.,
NørregaardHansen K.,
Paulev P.E.
Publication year - 1982
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1982.tb00618.x
Subject(s) - platelet , medicine , endocrinology , coagulation , chemistry
6 long distance runners from the Danish marathon elite and 6 non‐runners completed test runs of 28 and 12 km, respectively. Distance runners and non‐runners showed the same responses in platelet function. We found a significant decrease in ADP induced platelet aggregability, a decreased serotonin release induced by ADP and collagen and an increase in platelet factor 4 immediately following the run. The antithrombin III levels remained constant. Euglobulin lysis time was shortened (by approximately 50 %) and the plasminogen levels significantly increased. The last 2 findings indicate an equal increase in fibrinolytic activity during distance running in both groups. While short term, strenuous exercise induces platelet hyperaggregation, long term distance running induces a state of exhaustion of platelet aggregation capacity.