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Inhibitory Effect on Monocyte‐Mediated Cytotoxicity of Sera from Patients with Multiple Myeloma and Malignant Lymphoma
Author(s) -
Eggen Bjørn Magne,
Lamvik Jon O.,
Unsgaard Geirmund
Publication year - 1982
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1982.tb00612.x
Subject(s) - cytostasis , monocyte , cytotoxicity , medicine , lymphoma , multiple myeloma , immunology , in vitro , cytolysis , cancer research , chemistry , biochemistry
There was no difference in monocyte‐mediated cytotoxicity between monocytes from patients with multiple myeloma or malignant lymphomas and monocytes from control persons after in vitro culture for 5 d. Cytostatic and cytolytic ability of lymphokine‐activated monocytes cultured in medium with patient serum was significantly depressed compared to the ability of monocytes cultured with normal serum. A similar depression of cytostasis was found with non‐activated monocytes of both patient and control origin. Sera from myeloma and lymphoma patients impaired the monocyte‐mediated cytotoxicity equally.