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Two Different in Vitro Growth Patterns for Erythroid Precursors in 18 Patients with Pure Erythrocytosis
Author(s) -
Clement S.,
Eberlin A.,
Najean Y.,
Chedeville A.
Publication year - 1982
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1982.tb00601.x
Subject(s) - erythropoietin , progenitor cell , haematopoiesis , abnormality , medicine , endocrinology , homeostasis , stem cell , immunology , biology , microbiology and biotechnology , psychiatry
Growth patterns of marrow and blood erythroid progenitors were studied in 18 cases of pure erythrocytosis using different doses of erythropoietin. 8 cases demonstrated ‘spontaneous’ growth of CFU‐E and blood BFU‐E as observed in myeloproliferative disorders, but without an excess of circulating CFU‐GM. 3 of these patients also had other symptoms of a pan‐myelopathy. All these cases showed good sensitivity to 32 P myelo‐suppression. 10 cases demonstrated growth patterns of erythroid progenitors similar to those observed in normal subjects, except for an excess of blood BFU‐E, which suggests an abnormality of homeostatic regulation. In 5 of these cases, myelo‐suppression was not effective. It is suggested that a stem cell study could differentiate patients with pure erythrocytosis due to ‘autonomous’ abnormal stem cell growth from cases due to abnormal regulation factors, and that such a discrimination might be useful for the choice of therapy.