Premium
A Case of Severe Aplastic Anaemia Successfully Treated by Retransplantation from the Same Donor
Author(s) -
Noguchi Koji,
Ifuku Hideki,
Ohe Yokiko,
Okamoto Takahiro,
Fujita Shigeru,
Kanamuru Akihisa,
Nagai Kiyoyasu,
Kai Shunro,
Hara Hiroshi,
Uchino Haruto,
Yamagishi Shikyu,
Yoshida Yataro
Publication year - 1982
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1982.tb00598.x
Subject(s) - cyclophosphamide , medicine , total body irradiation , surgery , transplantation , bone marrow transplantation , graft vs host reaction , sibling , haematopoiesis , disease , chemotherapy , stem cell , biology , psychology , developmental psychology , genetics
A 16‐year‐old girl with severe aplastic anaemia was successfully treated with retransplantation of bone marrow from an HLA‐identical sibling after rejection of the first transplantation from the same donor. Cyclophosphamide was used for the first transplantation and cyclophosphamide, 300 rad total‐body irradiation and antilymphocyte globulin were used for the second transplantation. Permanent engraftment was achieved after the retransplantation with normalization of haemopoiesis, which has lasted for over 17 months. The patient is now in excellent clinical condition with minimal signs of chronic graft versus host disease.