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A Family with Reduced Plasminogen Activator Activity in Blood Associated with Recurrent Venous Thrombosis
Author(s) -
Jorgensen Maja,
Mortensen Jens Zobbe,
Madsen Anne Grete,
Thorsen Sixtus,
Jacobsen Bo
Publication year - 1982
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1982.tb00586.x
Subject(s) - venous thrombosis , medicine , venous blood , thrombosis , plasminogen activator , cardiology
6 members of a family with a tendency to thrombosis and defective fibrinolysis were examined. After stimulation of plasminogen activator release from the vessel wall by local venous occlusion or by submaximal physical exercise, they had a lower plasminogen activator activity in blood than a healthy control group (P < 0.01). 5 of the examined members suffered from recurrent venous thrombosis. The defect appeared to be autosomal dominant.