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Multiple Myeloma with a Sarcoidosis‐Like Reaction
Author(s) -
Falini Brunangelo,
Tabilio Antonio,
Velardi Andrea,
Cernetti Cristina,
Aversa Franco,
Martelli Massimo F.
Publication year - 1982
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1982.tb00585.x
Subject(s) - sarcoidosis , pathology , immunoperoxidase , multiple myeloma , histiocyte , granuloma , epithelioid cell , medicine , bone marrow , lymph node , lymphoma , systemic disease , giant cell , disease , immunology , immunohistochemistry , antibody , monoclonal antibody
An unusual case of multiple myeloma with extramedullary dissemination and co‐existing systemic non‐necrotic granulomas is described. Immunoperoxidase staining revealed that both lymph node and bone marrow infiltrating plasma cells contained the same IgG‐Λ type paraprotein, and that the granuloma epithelioid histiocytes contained intracytoplasmic lysozyme. As there was no evidence of either systemic infection or sarcoidosis, the nonnecrotic granulomas may represent the host's response to the myeloma, not unlike the reaction observed in Hodgkin's disease or solid tumours. A causal association cannot, however, be entirely excluded.