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Enhanced in Vivo Platelet Activation in Diabetes Mellitus
Author(s) -
Ek I.,
Thunell S.,
Blombäck M.
Publication year - 1982
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1982.tb00581.x
Subject(s) - medicine , endocrinology , diabetes mellitus , platelet factor 4 , platelet , platelet activation , thrombin , urinary system , in vivo , coagulation , cholesterol , insulin , chemistry , biology , microbiology and biotechnology
Plasma levels of platelet factor 4 (PF4) determined in 58 apparently healthy subjects were found to increase with age. In 66 insulin dependent diabetics, PF4 plasma levels were increased but unrelated to the age of subject. Mean fibrinopeptide A levels were elevated in the diabetics but not correlated to PF4 levels. Activation of the coagulation system with thrombin generation thus seems to be operative in diabetes, but the enhanced platelet activation also observed in this disease is probably not thrombin mediated. No correlation was found between PF4 plasma concentration and the degree of vascular complication, HbA 1c , blood glucose, 24‐h urinary glucose, serum cholesterol or serum triglycerides.