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Acute Erythroleukaemia with L3 Morphology and the 14q+ Chromosome
Author(s) -
Ekblom Marja,
Elonen Erkki,
Vuopio Pekka,
Hein Kristiina,
Knuutila Sakari,
Gahmberg Carl G.,
Andersson Leif C.
Publication year - 1982
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1982.tb00566.x
Subject(s) - morphology (biology) , chromosome , biology , chromosome morphology , genetics , karyotype , gene
L3 morphology according to the FAB classification and the 14q+ chromosome are usually ascribed to the Burkitt type of leukaemia or lymphoma with a B or pre‐B cell phenotype. We report here a case of adult acute leukaemia with Burkitt morphology and the 14q+, which did not express lymphoid markers. Instead, the leukaemia was shown to be an acute erythroleukaemia. The erythrocyte marker glycophorin A was present on the surface of the leukemic blasts as shown by immunofluorescence and immunoprecipitation from membrane lysates of surface labeled cells with antiglycophorin A antiserum. Spectrin and fetal hemoglobin appeared after cultivation of the blasts in the presence of sodium butyrate. The present case shows that a short term cultivation is sometimes useful for further characterization of the commitment of acute leukaemias.