Premium
The Effect of Intranasal DDAVP on Coagulation and Fibrinolytic Activity in Normal Persons
Author(s) -
Nilsson Inga Marie,
Mikaelsson Marianne,
Vilhardt Hans
Publication year - 1982
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1982.tb00565.x
Subject(s) - nasal administration , vasopressin , fibrinogen , medicine , coagulation , endocrinology , platelet , arginine , chemistry , immunology , biochemistry , amino acid
DDAVP (l‐desamino‐8‐D‐arginine vasopressin) was administered intranasally to 20 normal persons and blood was collected at various intervals up to 72 h. Plasma concentrations of VIILC, VIIIR:Ag and fibrinolytic activity were increased by DDAVP with peak levels observed 1 h after the administration. Factors V, IX, XI, XII, XIII, P‐APT time, platelets, platelet factor 3, P&P, AT III, α 2 AP, fibrinogen and FDP were unchanged by the treatment. No side effects or changes in plasma Na or osmolality were observed. The present data demonstrate the selectivity of the effect of DDAVP on the coagulation system and points towards the possibility of using DDAVP in blood donors to increase plasma contents of factor VIII.