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‘μ’ Heavy Chain Type ‘Non‐Excretory’ Myeloma
Author(s) -
Guglielmo Patrizia,
Granata Pasquale,
Raimondo Francesco Di,
Lombardo Turiddu,
Giustolisi Rosario,
Cacciola Elio
Publication year - 1982
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1982.tb00559.x
Subject(s) - immunoglobulin light chain , excretory system , cytoplasm , multiple myeloma , bone marrow , plasma cell , monoclonal , secretion , heavy chain , plasma cell myeloma , chemistry , urine , biology , antibody , pathology , monoclonal antibody , endocrinology , microbiology and biotechnology , medicine , immunology
An unusual case of ‘non‐excretory’ myeloma is described in which, using immunofluorescen‐ce, only ‘\i’ heavy chains were detected in almost all bone marrow plasma‐cell cytoplasm. Cytoplasmic light chains were completely lacking, and neither monoclonal whole immuno‐globulin (Ig) nor free heavy nor light chains were detected in serum and urine, although the clinical and morphological features showed the classical pattern of myeloma. The possible mechanism which could play a role in the disturbance of the Ig‐chain secretion observed in this case is discussed.