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Iron Absorption in Patients with Chronic Uraemia
Author(s) -
Milman Nils
Publication year - 1982
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1982.tb00555.x
Subject(s) - medicine , gastroenterology , chronic renal failure , iron status , ferritin , transferrin , absorption (acoustics) , renal function , serum ferritin , red cell , urology , iron deficiency , anemia , physics , acoustics
The purpose of this study was to examine the accuracy of iron absorption calculated from the incorporation of radioiron into red cells (RCI), compared to measurement by the whole body counting technique (WBR). RCI of orally administered 59 Fe, and absorption of 59 Fe assessed by WBR were measured simultaneously in 53 chronic uraemic patients (16 non‐dialysed, 18 peritoneal dialysed, 19 haemodialysed), 14 renal transplanted patients with normal renal function, and 27 healthy subjects. In the majority of subjects RCI values were lower than corresponding WBR values, with mean red cell 59 Fe utilization values (RCI/WBR ratio x 100) in the various groups from 78% to 93%. All groups demonstrated significant correlations between RCI and WBR with r values from 0.963 to 0.996 (P<0.001). RCI was higher in patients with reduced marrow iron stores than in patients with adequate iron stores (P<0.001), and was correlated both to plasma transferrin (r = 0.59, P<0.001) and serum ferritin (r = ‐0.88, P <0.001). In all groups there was good accuracy of calculated iron absorption (from RCI) compared to ‘true’ iron absorption (by WBR) with r values from 0.963 to 0.995 (P <0.001). Iron absorption measurement based on red cell incorporation appears to be a practical and accurate alternative to whole body counting, both in healthy subjects and in patients with chronic uraemia.