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E Receptor Expression of T Lymphocytes in T Lymphoproliferative Diseases
Author(s) -
Jønsson V.,
Andersen B. Lasthein,
Brandrup F.,
Christensen B. E.,
R.Othenborg H. W.,
Thomsen K.
Publication year - 1982
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1982.tb00534.x
Subject(s) - mycosis fungoides , lymphoproliferative disorders , receptor expression , atopic dermatitis , immunology , t lymphocyte , receptor , medicine , bone marrow , t cell , pathology , lymphocyte , lymphatic system , allergy , biology , lymphoma , antigen , immune system
The lymphoid component of skin infiltrates from 6 cases of mycosis fungoides and 2 cases of T cell chronic lymphatic leukaemia consisted almost exclusively of T lymphocytes with abnormally high E receptor expression. Such T cells were also found to dominate the skin infiltrates from 10 patients with severe atopic dermatitis. Blood T lymphocyte counts from all types of patients were within the normal range, but even the blood T lymphocytes of the patients had a strong E receptor expression. The bone marrow in atopic dermatitis and in mycosis fungoides showed normal T cell counts with normal E receptor expression. Supported by basic lymphocyte‐kinetic considerations it is likely that the skin in T lymphoproliferative diseases is characterized by an abnormal ability to home and/or to trap T lymphocytes with strong E receptor expression.