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A Comparison of Tetrahydrofolate and 5‐Formyltetrahydrofolate in Correcting the Impairment of Thymidine synthesis in Pernicious Anaemia
Author(s) -
Deacon Rosemary,
Chanarin I.,
Perry Janet,
Lumb M.
Publication year - 1982
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1982.tb00529.x
Subject(s) - pernicious anaemia , thymidine , deoxyuridine , bone marrow , medicine , formylation , biochemistry , chemistry , dna , catalysis
5‐formyltetrahydrofolate and tetrahydrofolate were added to marrow cells from patients with untreated pernicious anaemia at 1, 5 and 50 nmol doses in the deoxyuridine suppression test. At all 3 dose levels formyltetrahydrofolate was significantly more effective in correcting the defect of thymidine synthesis in pernicious anaemia, than tetrahydrofolate. The data suggest that formylation of tetrahydrofolate is necessary for its normal utilization.