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Diurnal Variations in Cobalamin Binding Plasma Proteins
Author(s) -
Brynskov Jørn,
Gimsing Peter
Publication year - 1982
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1982.tb00506.x
Subject(s) - cobalamin , plasma protein binding , blood proteins , chemistry , biochemistry , vitamin b12
The diurnal variations in cobalamin‐binding plasma proteins were studied in 10 healthy volunteers. The unsaturated cobalamin‐binding capacities of transcobalamins (TC‐II and R‐binders), P‐cobalamin and P‐protein were measured every third hour during 24 h. Only small variations within an interval of ± 20% were found. Highly significant decrements during the night were a uniform finding. After correction for variations of total plasma protein, the changes became less prominent, but still significant for P‐cobalamin and P‐R‐binders. Hence the mean values of P‐R‐binders and P‐cobalamin were 113 and 533 pmol/1 at 9:00 h, and decreased 12 and 8%, respectively, at 3:00 h. When using cobalamin binding plasma proteins in the monitoring of various malignant, haematological and autoimmune disorders, the specimens should, therefore, be collected at defined hours and in a uniform posture.