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Identification of a Chemokinetic Inhibitor in Serum from Patients with Chronic Lymphocytic Leukaemia
Author(s) -
Siegbahn Agneta,
Venge Per,
Nilsson Kenneth,
Simonson Bengt
Publication year - 1982
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1982.tb00504.x
Subject(s) - antibody , inhibitory postsynaptic potential , immunology , medicine , chronic lymphocytic leukemia , neutrophile , chemistry , leukemia , inflammation
The effects of serum from patients with chronic lymphocytic leukaemia (CCL) on normal polymorphonuclear leucocyte migration (PMN) were examined by means of the leading front technique, using a modified Boyden chamber. 18 randomly selected patients were studied. 13 patients had a reduced chemokinetic activity. The defective migration was explained by the finding in serum from these patients of cell‐directed inhibitory activity which was destroyed by heating (56°C, 30 min). The B‐lymphocytes as the origin of the inhibitory activity was suggested by the presence of a similar activity in supernatants from cultured tumour cells. 6 of the 18 patients had the combination of a defective chemokinetic activity and low levels of immunoglobulins. These 6 patients had an increased tendency towards infections.