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Chronic Idiopathic Thrombocytopenic Purpura (ITP): Site of Platelet Sequestration and Results of Splenectomy
Author(s) -
Gugliotta Luigi,
Isacchi Giancarlo,
Guarini Anna,
Ciccone Fabrizio,
Motta Maria Rosa,
Lattarini Cynthia,
Bachetti Giuseppe,
Mazzucconi Maria Gabriella,
Baccarani Michele,
Mandelli Franco,
Tura Sante
Publication year - 1981
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1981.tb01682.x
Subject(s) - splenectomy , medicine , platelet , gastroenterology , thrombocytopenic purpura , purpura (gastropod) , spleen , surgery , ecology , biology
51 Cr‐platelet kinetics study was performed in 197 patients with chronic ITP after corticosteroid therapy had failed to induce a long lasting remission. The incidence of splenic, spleno‐hepatic, hepatic and diffuse platelet sequestration site was 58 %, 17 %, 6% and 19 %, respectively. Splenic and spleno‐hepatic sequestration sites were more frequent in patients less than 30 years old and in patients with a platelet count lower than 50 times 10 9 /1. Ill patients were splenectomized shortly after the study. Normalization of the platelet count was obtained more frequently in patients with splenic and spleno‐hepatic sequestration than in the others. Labelled platelet sequestration site was the best predictor of the outcome of splenectomy. Platelet kinetics is a non‐invasive investigation that should be performed early after the diagnosis of chronic ITP in all patients eligible for splenectomy.