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Coexisting Suppressor Cells for Myeloid Colony Formation in the Bone Marrow of Patients with Aplastic Anaemia
Author(s) -
Hinterberger Wolfgang,
Muhar Ulrike,
Mcller Renate,
Arne Olaf,
Kabrna Jurgenssen Eva,
Paukovits Walter R.
Publication year - 1981
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1981.tb01672.x
Subject(s) - bone marrow , suppressor , medicine , immunology , myeloid , cancer
Suppressor cells for colony forming cells (CFUc) were found in the bone marrow of 1 of 6 patients with aplastic anaemia. The assay applied was based on the fact that coexisting suppressor cells are more sensitive to dilution than CFU C , as long as adequate stimulation is provided by a source of colony stimulating activity. In the patient with suppressor cells, a 4 d trial of 1000 mg methylprednisolone per d failed to improve the blood cell production and had to be discontinued due to gastric irritation.