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Subpopulations of T‐Lymphocytes in Multiple Myeloma
Author(s) -
Pezzutto A.,
Semenzato G.,
Agostini C.,
Raimondi R.,
Gasparotto G.
Publication year - 1981
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1981.tb01670.x
Subject(s) - multiple myeloma , suppressor , in vitro , receptor , immunology , t cell , cancer research , microbiology and biotechnology , medicine , chemistry , endocrinology , biology , immune system , cancer , biochemistry
The percentage and absolute numbers of T lymphocytes bearing Fc receptor for IgG and IgM were evaluated in 13 patients with multiple myeloma and in a group of controls of the same age range. An increase in the percentage of T G cells was found, whereas T M cell numbers were not different from those of the controls. In order to better define the properties of the T G lymphocytes, their ability to suppress the PWM‐induced B cell differentiation was tested in an in vitro experimental assay. T G cells from multiple myeloma exert a suppressor activity as the T G of the controls in this system. The possible interpretation of suppressor T cell increases in these patients is discussed.