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Chromosome Studies in Acute Lymphoblastic Leukaemia (ALL)
Author(s) -
BorgstrOm G. H.,
Teerenhovi L.,
Vuopio P.,
Andersson L. C.,
Elonen S. Knuutila E.,
Chapelle A. de la
Publication year - 1981
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1981.tb01652.x
Subject(s) - bone marrow , chromosome , karyotype , cytogenetics , philadelphia chromosome , pathology , lymphoblastic leukemia , biology , chromosome analysis , medicine , immunology , chromosomal translocation , leukemia , genetics , gene
Chromosome banding studies of the bone marrow were performed in 35 adult (> 14 years) patients with acute lymphoblastic leukaemia (ALL). Surface marker analysis was done in 24 of these and revealed 4 B‐ALL, 5 T‐ALL and 15 non‐T non‐B ALL. Most patients were studied at diagnosis before any treatment. A clonal karyotypic abnormality was found in 16 patients (46 %) initially. A Philadelphia chromosome was found in 3 patients, all belonging to the non‐T non‐B group. 5 patients, who all had blast cells with morphologic characteristics of Burkitt type L 3 , were found to have bone marrow cells with a 14q+ marker chromosome. In at least 4 cases this was due to a t(8;14). The cytogenetic findings showed some correlation to the ALL subgroup, but not to the response to treatment or the prognosis.