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High‐Affinity Folate Binding in Chronic Myelogenous Leukaemia Serum, Relationship of Binding Characteristics to Activity of Disease and Binder Concentration
Author(s) -
Holm Jan,
Hansen Steen Ingemann,
Lyngbye Jørgen
Publication year - 1981
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1981.tb01639.x
Subject(s) - disease , chemistry , chronic myelogenous leukemia , medicine , immunology , leukemia
High‐affinity binding of [ 3 H]folate to chronic myelogenous leukaemia serum displayed positive co‐operativity. There seemed to be a relationship between the concentration level of binder in serum and the activity of the disease in the sense that the serum level of binder during remission fell to a value similar to that of normal serum. This was accompanied by a shift from positive co‐operativity to the binding type of normal serum, i.e. negative co‐operativity. The data support the hypothesis that the different characteristics of high‐affinity folate binding in chronic myelogenous leukaemia and normal serum are related to parallel differences in the serum level of binder.