Premium
Platelet Function in Preleukaemia
Author(s) -
Lintula R.,
Rasi V.,
Ikkala E.,
Borgström G. H.,
Vuopio P.
Publication year - 1981
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1981.tb01626.x
Subject(s) - platelet , thrombocytosis , myeloproliferative disorders , ristocetin , bone marrow , bleeding time , preleukemia , epinephrine , blood platelet disorders , megakaryocyte , medicine , platelet aggregation , pathology , biology , haematopoiesis , microbiology and biotechnology , stem cell
Platelet function was studied in 17 patients with preleukaemia and the results were compared with those of 28 patients with other chronic myeloproliferative disorders. The test pattern included bleeding time (Ivy), platelet retention (Hellem II), PF‐3 activity and availability after exposure to ADP and kaolin, and ADP‐, epinephrine‐, collagen‐ and ristocetin‐induced aggregations. Platelet function was frequently impaired in patients with preleukaemia. The defects were similar to those found in other myeloproliferative disorders. The most consistent finding was defective aggregation. Patients with thrombocytosis and/or with increased amounts of megakaryocytes in the bone marrow had fewer defects in platelet function. Retention defect was more common in patients with hypolobulated megakaryocytes, especially in those having a specific marker, the 5q‐ chromosome, in their bone marrow cells.