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Alpha‐Tocopherol and Cardiac Toxicity of Iron
Author(s) -
Lindvall S.,
Rydén L.,
Smedgård P.,
Swedberg B.
Publication year - 1981
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1981.tb01411.x
Subject(s) - malabsorption , alpha tocopherol , toxicity , scavenger , tocopherol , vitamin e , medicine , gastroenterology , endocrinology , chemistry , antioxidant , biochemistry
At the onset of disturbances of cardiac rhythm after a 7th injection of iron sorbitol to a patient with severe malabsorption syndrome an extremely low level of alpha‐tocopherol in serum – 0.04 mg per 100 ml serum – was observed. The clinical manifestations are interpreted as a possible consequence of the depletion of the vitamin, a natural scavenger of free radicals. The possible importance of alpha‐tocopherol in preventing the toxic effect of iron on the apparently very sensitive myocardium after parenteral iron to patients with severe malabsorption syndrome is discussed.