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An Association between Thalassaemia and Autoimmune Haemolytic Anaemia (AIHA)
Author(s) -
Kruatrachue M.,
Sirisinha S.,
Pacharee P.,
Chandarayingyong D.,
Wasi P.
Publication year - 1981
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1981.tb01398.x
Subject(s) - antibody , immunology , splenectomy , medicine , antiserum , autoimmune hemolytic anemia , coombs test , evans syndrome , blood transfusion , thalassemia , spleen
An association between thalassaemia and autoimmune haemolytic anaemia (AIHA) has not been previously recognized. 10 patients with thalassaemic diseases were found to give positive results to antiglobulin test with polyvalent antiserum. Tests with monovalent antisera revealed immunoglobulins on the red cells in all cases. From history of blood transfusion, auto‐antibodies following alloimmunization were very unlikely. IgG, either alone or together with IgM or IgA, was the predominant antibody on the red cells. All cases had warm type AIHA and responded dramatically well with steroid treatment except 3 who eventually needed splenectomy which responded in 2 and failed in 1.