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Erythrocyte Superoxide Dismutase, Catalase and Glutathione Peroxidase Activities in β‐Thalassaemia (Major and Minor)
Author(s) -
Gerli G. C.,
Beretta L.,
Bianchi M.,
Pellegatta A.,
Agostoni A.
Publication year - 1981
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1981.tb01370.x
Subject(s) - catalase , superoxide dismutase , antioxidant , glutathione peroxidase , enzyme , biochemistry , peroxidase , chemistry , red blood cell , glutathione
The ‘antioxidant’ enzymes superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH‐Px) were found greatly elevated in red blood cells of subjects with β‐thalassaemia minor and similar to normal values in red blood cells of subjects with β‐thalassaemia major. These findings allows us to speculate that red cells in β‐thalassaemia minor react to the increased oxidant threat with augmented antioxidant enzyme activities. The normal levels of antioxidant enzymes in β‐thalassaemia major seem to be due to the presence of normal red cells owing to multiple transfusions.