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Severe Antithrombin III Deficiency in a Patient with Pre‐Eclampsia.
Author(s) -
Büller Harry R.,
Weenink Ad H.,
Treffers Pieter E.,
Kahlé Laurens H.,
Otten Hans A.,
Cate Jan W.
Publication year - 1981
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1981.tb01369.x
Subject(s) - disseminated intravascular coagulation , antithrombin , medicine , antithrombin iii deficiency , heparin , coagulation , eclampsia , caesarian section , gastroenterology , pregnancy , biology , genetics
Severe acquired antithrombin III (AT III) deficiency was observed in a patient with severe pre‐eclamptic toxaemia. Plasma AT III concentration of 0.25 U/ml was found in both functional and immunological assays. The patient was treated with human AT III concentrate as a result of the development of progressive disseminated intravascular coagulation (DIC), the further deterioration of renal function, the risk for thromboembolic complications and the possible adverse effects of heparin therapy. The selective correction of AT III activity resulted in a rapid disappearance of coagulation abnormalities. The patient underwent uncomplicated caesarian section. This observation indicates that acquired severe AT III deficiency may occur as an early feature of DIC in severe pre‐eclamptic toxaemia.