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Dosage of Acetylsalicylic acid for Inhibition of Platelet Function
Author(s) -
Huijgens P. C.,
Berg C. A. M.,
Meer C.,
Imandt L. M. F. M.,
Langenhuijsen M. M. A. C.
Publication year - 1981
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1981.tb01368.x
Subject(s) - malondialdehyde , aspirin , platelet , chemistry , prostaglandin , bleeding time , arachidonic acid , pharmacology , platelet aggregation , medicine , biochemistry , oxidative stress , enzyme
In normal males, platelet prostaglandin synthesis as measured by malondialdehyde (MDA) production is blocked by more than 90% after administration of 600 mg of calciumacetylsalicylic acid and by more than 50% after 100 mg. Repeated doses of 100 mg at 12 h intervals progressively decrease MDA production to below 10% of the basic value. Bleeding time increases from 3.38 ± 0.36 min to 7.73 ± 0.91 min (mean ± SEM). The data indicate that 12 h 100 mg doses of calciumacetylsalicylic acid (equal to 80 mg of aspirin) adequately inhibit platelet function.