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Spontaneous Transformation of Low Density Lymphocytes as Parameter of Activity in Hodgkin's Disease
Author(s) -
Pauw B. E.,
Mulder P. H. M.,
Smeulders J. B. J. M.,
Wagener D. J. Th.,
Haanen C.
Publication year - 1981
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1981.tb01365.x
Subject(s) - thymidine , disease , lymphocyte , transformation (genetics) , medicine , dna , gastroenterology , immunology , chemistry , biochemistry , gene
Analysis of spontaneous lymphocyte transformation, as measured by 3 H‐thymidine incorporation by low density lymphocytes, before and after therapy was performed in 28 patients with Hodgkin's disease. Before treatment increased 3 H‐thymidine uptake was found in 24 out of 28 patients. Following therapy the spontaneous lymphocyte transformation of the patients in clinical remission returned to the normal range, whereas none of the patients with residual disease achieved these levels. The overall correlation between the uptake of the DNA precursor by low density, lymphocytes and disease activity after treatment was excellent.