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Vincristine and Prednisolone Therapy in Blast Crisis of Chronic Myelogenous Leukaemia in Childhood
Author(s) -
Kano Y.,
Takaku F.,
Sakamoto S.,
Hida K.,
Kasahara T.,
Okamura J.,
Hasegawa K.,
Tsukada T.,
Sasaki H.
Publication year - 1981
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1981.tb00492.x
Subject(s) - blast crisis , prednisolone , vincristine , medicine , chronic myelogenous leukemia , precursor cell , prednisone , immunology , leukemia , chemotherapy , cyclophosphamide , biology , in vitro , biochemistry
6 cases of chronic myelogenous leukaemia (CML) blast crisis in childhood were treated with vincristine and prednisolone (V‐P). In 3 terminal transferase (TdT)‐positive cases, blast cells were lymphoid in appearance. All 3 TdT‐positive patients entered a complete remission but developed meningeal leukaemia. The mean duration of survival from the onset of blast crisis was 32 months. In 3 TdT‐negative cases, V‐P therapy was ineffective. The results of this study suggest that V‐P therapy is more effective for CML blast crisis in childhood with TdT positive blast cells and that prophylactic central nervous system treatment is necessary to prevent meningeal leukaemia.